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The silent side effect of metformin: understanding Vitamin B12 deficiency in Type 2 Diabetes | Acta Diabetologica | Springer Nature Link https://ruo.bio/wp-content/uploads/2025/09/ace031-300x300.png mthfr support Size:Inner A multicenter trial of 390 patients with diabetes mellitus receiving insulin therapy who were randomized to receive metformin, 850 mg three times daily, or placebo assessed the risk of vitamin B 12 deficiency and low vitamin B 12 levels over four years

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