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Methotrexate is a folate antagonist that inhibits DNA synthesis by blocking dihydrofolate reductase (DHFR). It is commonly used for rheumatoid arthritis, psoriasis, ectopic pregnancy, and certain cancers. Important adverse effects include hepatotoxicity https://careercenter.umich.edu/sites/default/files/inline-images/PSIP_Est1969_0.png Now Foods Size:60 Vegetarian Capsules 10.3390/ijms18122679 [DOI] [PMC free article] [PubMed] [Google Scholar] 119.Xia X, Ding M, Xuan J et al (2020) Functional polymorphisms and transcriptional analysis in the 5′ region of the human serotonin receptor 1B gene ( HTR1B ) and their associations with psychiatric disorders

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