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3.3 HMGCR exerts tumor inhibition through the Hippo pathway The Hippo pathway primarily regulates cell proliferation (51) and is a major tumor suppressor pathway

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For instance, as learned by X-ray crystallographic studies of complexes of the enzymes with glutathione alkyl thioethers as non-covalent inhibitors, in human α class glutathione transferase A1-1 the sulphur atom forms a hydrogen bond to the hydroxyl group of a tyrosine and to the guanido group of an arginine [130,131,132]