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The N-terminal “tails” of these histones undergo various modifications-acetylation, phosphorylation, methylation, and ubiquitination—that affect their interaction with DNA, thereby altering chromatin structure and regulating gene expression 15,88
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Figure 2 2.1.1 BCAT4: The gateway enzyme Branched-Chain Aminotransferase 4 (BCAT4) initiates the pathway by catalyzing the transamination of L-methionine to 4-methylthio-2-oxobutyrate (MTOB)
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