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Specifically, the opposing correlations of tryptamine and xanthurenic acid imply a relative redirection of peripheral tryptophan flux Notably, microbial depletion via antibiotics further worsened memory retention deficits, yet it did not further reduce hippocampal BDNF, synaptophysin (SYP), or postsynaptic density protein 95 (PSD-95) expression (Zeng et al., 2025)

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