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In addition, as of January 1, 2019, CMS now allows beneficiaries to use the Special Election Period (SEP) for dual eligible and LIS individuals once per calendar quarter for the first 3 quarters of the year: 1st Quarter – January to March 2nd Quarter – April to June 3rd Quarter – July to September AEP – October 15 to December 7 The quarterly usage is based on the application date, not the effective date
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Thus, Nrf2 activates many genes ininvolved to ROS reduction, serving as a master transcription factor for maintaining redox homeostasis [67]
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