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Challenges and prospects in GBM therapy The treatment of GBM remains profoundly challenging in oncology because of the resilience and plasticity of GSCs, extensive tumor heterogeneity, the highly immunosuppressive TME, metabolic adaptability, and the BBB
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Pre dose levels, however, were only significantly higher in the groups taking 1.5g twice daily (p = 0.03) or 2g once daily (p = 0.008)
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