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The role of the active site lysine residue on FAD reduction by NADPH in glutathione reductase - ScienceDirect

The intricate interplay between aging and AD involves various biological mechanisms, including the accumulation of amyloid-beta plaques due to the abnormal processing of amyloid precursor proteins, formation of neurofibrillary tangles from hyperphosphorylated tau proteins, mitochondrial dysfunction leading to oxidative stress, and chronic inflammation propelled by activated macrophages and microglia [2, 3]

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the immuno-DASH inhibitor of Formula I is represented in Formula lb, or is a pharmaceutical salt thereof: R 1 is a lower alkyl R 9 is absent, or independently for each occurrence, is a lower alkyl, -OH, -NH 2 , -N3, -(lower alkyl)-C(0)OH, -O-lower alkyl, -0-(lower alkyl)-C(0)OH, -guanidinyl X is O each R 2 is hydrogen R 10 is absent, or represents a single substitution of -OH, -NH2, -CN or -N 3 W is -B(OH) 2 or - CN (and more preferably -B(OH) 2 )