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2025-05-12
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However, it is known that MPT can participate in several other forms of cell death ( The onset of MPT is characterized by the permeabilization of the MOM secondary to a sudden increase in permeability of the MIM, which allows the exit of molecules less than 1500 Da ( Oxidative stress induces MPT by targeting specific cysteine residues of cyclophillin D, which results in mitochondrial depolarization, oxidative phosphorylation uncoupling, release of intra-mitochondrial ions and metabolic intermediates, mitochondrial swelling and decrease in ATP synthesis
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