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At the systemic level, IR refers to a reduction in systemic insulin sensitivity, which can be assessed using measures such as the oral glucose tolerance test (OGTT) and the insulin tolerance test (ITT)
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In the latter case, it is possible to set defined technological parameters alongside the specific selective pressure, in order to select evolved strains, which possess both the specific phenotype and a good fermentative performance, sometimes even better than the parental one
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