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The nuclear factor-kappa B (NF-κB) pathway-critical for inflammation—is hyperactivated in M1 macrophages, leading to sustained cytokine production (93, 94)
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Intracellular Signaling Pathways Research involving GHRP-6 has examined intracellular signaling mechanisms associated with GHS-R1a activation, including phospholipase C (PLC), inositol trisphosphate (IP3), calcium-dependent signaling processes, and related signal-transduction pathways [1]
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