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Many of their targets are occurring on cyclooxygenase (COX), 5-lipoxygenase (5-LOX) and protein kinase B [92], which is associated with its ability to inhibit COX-1 and COX-2 activity along with transcription factors activity inhibition, directly involved in COX activity regulation [93]
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For example, a preclinical trial studying CD151, a member of the transmembrane four superfamilies that plays a key role in maintaining vascular stability, showed that its upregulation in the early phases of stroke is able to preserve BBB integrity (239), turning it into a possible therapeutic target
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