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It is part of the secretin/glucagon hormone family and signals through specific receptors (VPAC1 and VPAC2) on nervous, immune, and epithelial cells.​ Key physiologic roles include: Relaxing smooth muscle in blood vessels and the gastrointestinal (GI) tract, supporting vasodilation and motility.​ Modulating immune responses and lowering production of inflammatory mediators such as TNF‑alpha and IL‑6.​ Influencing circadian rhythm via its activity in the brain’s suprachiasmatic nucleus, which can impact sleep–wake patterns.​ VIP has been studied in cardiovascular, gastrointestinal, pulmonary, neuroendocrine, and immune systems for its broad regulatory effects

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The impact of leucine on these processes, and thus its effect on hypertension, is dependent on dietary intake of leucine and the increase in its concentration in skeletal muscle