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But chronic high-dose use may: Overstimulate metabolic pathways Alter methylation balance (since NNMT is tied to methyl donor cycling) Lead to unintended side effects like fatigue, irritability, or hormonal imbalance ✅ Stick to researched dosing windows (typically 10–20 mg/day for short cycles in animal models) ❌ 2
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10.1101/gad.1064703 [DOI] [PMC free article] [PubMed] [Google Scholar] Dong H., Guo W., Yue R., Sun X., Zhou Z
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