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ABHD5 R299 is close to D334 in our structural models, and mutagenesis analysis indicates a negatively-charged amino acid at 334 is necessary for ATGL activation
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Since AD is a multifactorial disease (see redox proteomics results that show many pathways affected because of secondary oxidative modification), the use of a single-molecule/single-target approach may result in limited efficacy
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US$40
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