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Ancillary benefits of dietary interventions, unrelated to the provision of macromolecules as energy fuel to solid tumors Despite that diet alone cannot fully starve a solid tumor of carbon and nitrogen nor deprive of ATP, it can still place the cancer at a systemic disadvantage by focusing on the following: (i) the insulin/Insulin Growth Factor (IGF) endocrine axis, (ii) the adipokine - cytokine - immune network, and (iii) the concentration of small “signal-metabolites” such as β-hydroxybutyrate that gate epigenetic reactions (Fig

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Accessed June 24, 2020