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For people with normal homocysteine levels (e.g., between 7-8), adding folic acid doesn’t statistically lower their homocysteine levels.[ref] When researchers compared adding more folate-rich foods (+350 mcg/day of folate) with a folic acid supplement (250 mcg/day of folic acid), they found that both groups had similar decreases in homocysteine.[ref] Who will this work best for

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More serious adverse effects also include hepatotoxicity, Steven-Johnson syndrome, and toxic epidermal necrolysis