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Many studies have reported that the downregulation of PGC-1ฮฑ was associated with abnormal mitochondrial biogenesis and diminished ATP production capacity, and the reduced mitochondrial biogenesis in hepatocytes by silica nanoparticles was also associated with the inhibition of the PGC-1ฮฑ/NRF-1/TFAM pathway (81)
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Due to the prevalence of allergic illnesses, they have been successfully used to identify anti-allergic drugs such as cetirizine, phenylephrine, dextromethorphan, and chlorpheniramine maleate (Rajpurohit and Srivastava, 2019)
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