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Several mechanisms have been recognized in the development of obesity-induced chronic inflammation including oxidative stress (148, 149), endoplasmic reticulum stress (150, 151), increasing oxygen consumption leading to adipocyte hypoxia (152, 153), inflammasome activation particularly NLRP3 (154, 155), and pattern recognition receptors (PRR) activation and regulation particularly TLR2 and TLR4 activation (156–158)

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Conclusion Our data indicate that the changing drug policy during 2008–2011, which provided the ACT, in the form of CoArtem, on subsidy in private retail shops and freely in public hospitals, had an effect on drugs used during the same period