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SIRT1, a NAD+-dependent deacetylase, mediates various biological functions including oxidative stress, aging, inflammatory response and autophagy via deacetylating multiple substrates, such as NF-κB (nuclear factor-kappaB), FOXOs (forkhead box O), and PPARγ (peroxisome proliferator-activated receptor γ) [7-11]

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Conclusions The paradigm shift toward precision medicine is highly dependent on the discovery, validation, and implementation of biomarkers [140]

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