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This process is mediated mostly by the superfamily of ATP-binding cassette (ABC) transporters , for example, MRP2 ( ABCC2 – ATP binding cassette subfamily C member 2) and BCRP ( ABCG2 – ATP binding cassette subfamily G member 2 [junior blood group]), which are expressed in the apical bile canalicular membrane

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The research on the variants: does not show that these variants are a problem does not indicate that everyone with the variants should be on low-sulfur or low-protein diets does not show that people with the variants should shell out money for specific ammonia-reducing supplements Instead, the research indicates that the common CBS variants may have a subtle effect on cholesterol levels