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Mitochondria-derived signals (mitokines, metabolites, mitochondrial damage-associated molecular patterns and vesicular mitochondrial cargo) create plausible routes for systems-level crosstalk that can propagate injury across organs

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Galangin likewise significantly induces apoptosis in renal cancer (Caki, ACHN and A498) cells but not normal cells by inhibiting NF-κB pathway activation, which induces downregulation of Bcl-2 protein and survivin expression at the transcriptional level (Hou et al., 2018)