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Dietary polyphenols, especially flavonoids, are thought to have strong antioxidant properties that help protect cells from ROS and oxidative stress (OS) playing a crucial role in preventing OS-related diseases and pathological conditions [131]
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227 In pathological iron overload, this DMT1 iron transport process is aggravated by increased TFR1 saturation, leading to the generation of toxic NTBI, which then causes β cell damage through ferroptosis
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