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Additionally, parabens have been shown to cross the blood-brain barrier, and its neurotoxicity has been linked to oxidative stress, inflammation, and neuronal damage (4,6,7)
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In hypoxia reduced expression of EAAT1 and 2 contributes to increase extracellular glutamate concentration leading to neuronal overexcitation and excitotoxicity (Rossi et al., 2007
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