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ROS are a necessary defense system to combat microbial respiratory infections (Lambeth, 2004), but oxidative stress and the excessive production of ROS by numerous cells including monocytes and macrophages, neutrophils, as well as pulmonary endothelial and epithelial cells play a major role in the development of ARDS and its complications during COVID-19 infections (Meftahi et al., 2021)

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Epitalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide that activates telomerase (TERT) in somatic cells, addressing the telomere attrition hallmark of cellular ageing — the progressive shortening of chromosomal telomeres that drives replicative senescence and HSC progenitor pool exhaustion