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Among macrophages, M1 macrophages secrete pro-inflammatory factors in the early stage, exacerbating renal injury, while M2 macrophages can promote tissue regeneration by secreting related factors, but their persistent infiltration can aggravate renal fibrosis (Gao et al., 2025
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However, it is essential to note that while these models can mimic many features of human CKD, they have limitations regarding disease progression rates, complications, and species differences
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