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CREB, a transcriptional regulator of BDNF and a downstream mediator of its activity [75,76,77,78], is also reduced in AD
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16 In this study, where the children were supplemented daily with two recommended daily allowances (RDA) for 6 months, the effect of vitamin B 12 supplementation was more apparent in children who had evidence of vitamin B 12 deficiency at the start of the study
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