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While HECT and RBR E3 ligases first couple active ubiquitin to an E3 ligase before transferring it to the substrate, RING E3 ligases catalyze the direct transfer of ubiquitin from E2 to the substrate
breaking down some free radicals
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These terms generally refer to enhancing mental performance through the non-medical use of specific pharmacological substances, such as drugs and medicines, and supplements in healthy individuals [2–4]
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