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Next, PPG IX is transported into the mitochondrial matrix, potentially via the transmembrane protein TMEM14C 30 , and oxidized to form protoporphyrin IX (PPIX) by the IMM enzyme protoporphyrinogen oxidase (PPOX) 22
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The susceptibility of tumor cells to ferroptosis is closely tied to their lipid composition, redox status, and iron availability, positioning lipid peroxidation as both a biomarker and a therapeutic target in cancer
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