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Additionally, tumor cells with mutations in isocitrate dehydrogenase 1 (IDH1) undergo metabolic changes, leading to elevated levels of 2-hydroxyglutarate (2-HG), which inhibits the activity of GPX4, promoting the accumulation of intracellular ROS (72)
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[DOI] [PMC free article] [PubMed] [Google Scholar] Srikanth K., Pereira E., Duarte A.C., Ahmad I
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