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31 These variants are additionally proposed to result in a more robust de novo thymidylate biosynthesis as a consequence of declining amounts of 5,10-methyleneTHF being available for irreversible reduction to 5-methylTHF via action of the MTHFR enzyme

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Even more troubling, pre-treatment with anti-anxiety agents in the rat defection model results in a greatly attenuated response, suggesting that it is much more suited to assess antipsychotic-induced anxiety/dysphoria than akathisia [55]