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Similarly, a stable temperature of 37°C during oocyte manipulation has been associated with improved fertilization rate [103]

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Given this gap between the understanding of the pathophysiology of CIRCI and its treatment, from our perspective, it is worrisome to generalize the prescription of corticosteroids as a rule disregarding the possible disruption of this fragile intracellular signalling structure, which may be more harmful in the short and long term