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The extensive application of antibiotics in veterinary medicine or animal farming may provoke the emergence and the distribution of antibiotic-resistant genes via horizontal gene transfer within and between bacterial species in the environment [84]

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For instance, GSTs promote the conjugation of GST with xenobiotics, superoxide dismutases partition the superoxide radical in oxygen and hydrogen peroxide, catalases decompose hydrogen peroxide into water and oxygen, peroxidases (POD) catalyze the oxido-reduction between hydrogen peroxide and reductants, and MDHAR, DHAR, ascorbate peroxidase (APX), and GRs are members of the ascorbate–glutathione cycle that detoxifies hydrogen peroxidase [9] (Figure 1)