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Main related signaling pathways and transcription factors of RA The activation of synovial cell TLR leads to exacerbation of arthritis (208), in which the expression of TLR2, TLR3, TLR4 and TLR5 in RA synovial cells is increased and they are involved in the regulation of inflammatory factor production in RA synovial cells
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There are still many issues to be investigated before drawing clear recommendations related to their use, including concerns related to their bioavailability, dosage, formulation, administration, possible interactions with treatments, and potential adverse effects for some patients in certain contexts
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