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Instead, Sirt3 deacetylates FOXO3 to increase the expression of mitophagy mediators (such as Bnip3, NIX, and LC3) [88]
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BPC-157 significantly enhances ERK1/2 phosphorylation in a dose-dependent manner, activating downstream targets including transcription factors c-Fos, c-Jun, and Egr-1
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