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Therefore, while low abundance of ACE2 protein is expressed in pancreatic beta and alpha cells, there is a robust enrichment of the SARS-CoV-2 entry proteins neuropilin 1 and transferrin receptor in beta cells, a mechanism that is potentially fundamental to its tropism for the pancreas 135,136
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It may also be of interest to test the effect of baicalin on human dermal and epidermal cells grafted onto immunodeficient mice (31) to determine whether the same effects of baicalin on Wnt/β-catenin signaling and DPC activity are observed in human-derived cells
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