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Frankly, it’s bordering on criminal that the FDA continues to allow these drugs to be prescribed as frequently as they are, and for durations of years or even decades in some cases, given the overwhelmingly large body of evidence documenting the potential harms associated with long-term PPI use

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The critical role of eNOS in controlling vascular tone was documented by findings that pharmacological inhibition of NOS causes hypertension (Rees et al., 1989) and deletion of NOS3 results in high blood pressure (Huang et al., 1995)