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On the other hand, to effectively cope with oxidative stress and electrophilic challenges under various environments, a large number of antioxidative enzyme systems exist in cells, including heme oxygenase-1 (HO-1), NADP(H) quinone oxidoreductase (NQO-1), and γ-glutamylcysteine synthetase (γ-GCLC) [45]
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In humans dietary fiber has been considered a mainstay of therapy for constipation, but a recent review concluded that many patients with more severe constipation have worsening symptoms when increasing dietary fiber intake
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