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Nlrp3 ablation in Nlrp3 Micro−/− and Nlrp3 Astro−/− mice shows that NLRP3 inflammasome regulates microglial activation, release of cytokines (TNF-α, IL-1α, and C1q) which promotes transformation of neurotoxic A1 astrocytes, neuronal death, and cognitive impairments in mice (Li S et al., 2022)
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