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Pascual et al., 2004), defective astroglial glutamate transportation (Rönnbäck and Hansson, 2004), hypoxia (Gibson et al., 1981), diabetes (Richardson, 1990), heart failure (Riegel et al., 2002), reduced glucose tolerance (Vanhanen et al., 1997), bradycardia, hypotension (Ackerman, 1996), stroke (van der Zwaluw et al., 2011), hypothermia, alcohol intoxication, thiamine and vitamin C deficiency, sedative-hypnotic drugs, opioids consumption (Martindale et al., 2010), general anesthesia (Parikh and Chung, 1995

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5.10.4 Vitamins and antioxidants Data from the Nurses Health Study (Troisi et al., 1995), a prospective investigation of major chronic diseases, suggests that anti-oxidant supplementation and intake of various fats during adulthood are not important determinants of asthma, although vitamin E from diet may have a modest protective effect