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Das Konstrukt verbindet eine Verlängerung um 13 Reste am N-Terminus mit der Substitution Glu3 → Arg innerhalb der reifen IGF-I-Domäne
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Within the ER limb, caspase-12—an ER-resident cysteine protease—becomes selectively activated, then engages caspase-9 and caspase-3 to drive apoptosis (134)
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