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We hypothesized that DJ-1 protects CoA or CoA precursors from aldehyde conjugation given that: 1) DJ-1 likely functions in mitochondrial homeostasis, 2) prokaryotic DJ-1 family proteins such as YraA and Hsp31/HchA are involved in aldehyde detoxification, and 3) YajL , the prokaryotic DJ-1 orthologue, comprises an operon with PanE that functions in the CoA biosynthetic pathway
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