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Sorafenib fails to trigger ferroptosis in cell lines with high xCT expression To further explore whether sorafenib may induce ferroptosis in cancer cell lines known to show robust xCT expression [15], human melanoma A375, lung cancer A549, hepatoma HLE, colon cancer HT29, breast cancer MDA-MB-436, glioma U-373, and kidney cancer UMRC2 cells were selected and the expression level of xCT was determined by immunoblotting (Fig
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