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Pro-inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin-1β (IL-1β), IL-6, and IL-18 are produced by chondrocytes in the synovium, which in turn trigger the production of factors such as matrix metalloproteinases (MMPs) that further augment cartilage degradation and apoptosis of chondrocytes (Sanchez-Lopez et al
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