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Mechanisms investigated Metabolic-pathway research converges on a small set of enzymatic and receptor targets, and these compounds map onto different ones โ they are not interchangeable: NNMT inhibition (5-Amino-1MQ): studied as a small-molecule inhibitor of nicotinamide N-methyltransferase, an enzyme implicated in cellular NADโบ/SAM metabolism
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However, lysine modification often yields heterogeneous products due to multiple reactive surface lysine residues in the antibody
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