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In 1986, Sen and Baltimoer first detected a nuclear protein factor that specifically bound to the immunoglobulin κ light chain gene enhancer κB sequence (GCGACTTTC) from mature B lymphocyte nuclear extract, called NF-κB
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In addition, NFAT can increase chromatin accessibility by recruiting the histone acetyltransferases CBP/p300, leading to H3K27 acetylation and facilitating the binding of glycolysis-promoting transcription factors, including HIF-1α (98, 99)
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