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Compared to radiation therapy, PDT and PTT can complement mainstay cancer treatments, overcome chemotherapy resistance, modify tumor perfusion, and vascular and extracellular matrix permeability, improve tumor drug delivery, provide greater spatiotemporal control, and lower the risk of secondary cancer development (Figure 2)

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The mitochondrial matrix is the space delimited by the inner membrane and contains the pyruvate dehydrogenase complex and the enzymes of the tricarboxylic acid cycle (TCA), the fatty acid oxidation, and the oxidation of amino acids [21] (Figure 6)