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For the same birth cohort, mortality rates increased markedly with age (e.g., for those born in 1958, mortality was 0.00034 at ages 30–34, rising to 0.068 at ages 60–64)

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Challenges in understanding the precise molecular basis underlying hypoxia-induced longevity Despite significant progress in elucidating the mechanisms underlying hypoxia-induced longevity, several challenges remain in understanding the precise molecular basis of this phenomenon