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Coumarins In search of tyrosinase inhibitors, the inhibitory effects of several coumarin derivatives (Figure 6) 277–279 such as 3-aryl and 3-heteroarylcoumarins 280 , esculetin 281 , coumarinolignoid 8'-epi-cleomiscosin 282 , umbelliferone and their analogs 283 , phenyl coumarins 284 , hydroxycoumarins 285 , 286 , thiophosphonic acid diamides, diazaphosphinanes coumarin derivatives 287 , cardol-coumarin derivatives 288 and coumarin-resveratrol hybrids 289 , were evaluated on tyrosinase activity