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Glutathione S-transferases P1-mediated interleukin-6 in tumor-associated macrophages augments drug-resistance in MCF-7 breast cancer - ScienceDirect

Multiple cellular changes occur following OTA exposure, which include decrease of Bcl-xL, survivin, (which lead to increases of apoptosis) and IL-2 and an increase of tumor necrosis factor alpha (TNF-α)

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Although a few proteins have been identified as thiol-sensitive, the specific mechanisms as to how thiols affect protein function remain unclear